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KMID : 0387419950060010061
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Korean Society of Oriental Neuropsychiatry
1995 Volume.6 No. 1 p.61 ~ p.70
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The Experimental Studies on the Anti-Stress Effeces of Chungkansoyosan
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Lim Seung-Hwan
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Abstract
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This study was aimed to evaluate the anti-stress effect of Chungkansoyosan on the rats stressed by immobilizaton.
The experimintal animals were immobilized in stress box (5㎝×5㎝×20㎝) for 12 hours in a day during 3 days, and administered 90ng/100g Chungkansouosan extract for 15 days before stress.
The epinephrine, dopamine contents in rat brain were measured by using HPLC method.
The following results were obtained:
1. Total cholesterol contents of control group was 58.1±2.56㎎/㎗, that of sample group was 61.6±3.70㎎/㎗. This shows decreasing effect, but not significant.
2. Triglyceride contents of control group was 39.8±6.75㎎/㎗ that of sample group was 27.7±4.23㎎/㎗. This shows significant decrease in sample group comparing to control group.
3.Epinephrine contents of control group was 8.21±0.31ng/㎎ that of sample group was 6.33±1.02ng/㎎ this shows significant decrease in sample group comparing to control group.
4. Dopamine contents of control group was 2.45±0.23ng/㎎ that of sample group was 1.65±0.41ng/㎎ this shows decreasing effect, but not significant.
5. The quantity of muscle relaxation by Rota Rod was improved significantly by Chungkcansoyosan in immobilizaton-stressed rats.
According to the above results, it is concluded that Chunkansoyosan will be useful as a preventive and remedy against stress disease.
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